Registry of Subjects at Risk of Pancreatic Cancer (NCT04095195) | Clinical Trial Compass
RecruitingNot Applicable
Registry of Subjects at Risk of Pancreatic Cancer
Italy1,000 participantsStarted 2019-08-20
Plain-language summary
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria to enter the registry:
* individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
* subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
* subjects suffering from FAMMM Syndrome
* subjects suffering from Peutz-Jeghers Syndrome
* subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
* subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
Inclusion criteria to join the "radiologic follow-up":
* 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
* 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
* 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome
Exclusion Criteria:
\- pregnancy
What they're measuring
1
This clinical study will assess the diagnostic yield of a clinical surveillance program for pancreatic neoplasia or predisposing conditions (PanIN, IPMNs) in high risk individuals
Timeframe: 25 years
Trial details
NCT IDNCT04095195
SponsorAssociazione Italiana per lo Studio del Pancreas