CompletedNot Applicable

Bicycle Exercise Echocardiography to Assess Physiological Significance of Mitral Annular Calcification

United States40 participantsStarted 2014-11-07

Plain-language summary

Many people develop calcium deposits in the heart as they get older. One of the common places for this to occur is the mitral annulus, the band of tissue that supports the mitral valve (one of four heart valves). The purpose of this study is to examine effects of these deposits (termed mitral annular calcification or "MAC") on a person's ability to perform exercise. The research team will use ultrasound of the heart (Doppler echocardiography) to study people with MAC while they exercise on a specially designed bicycle.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least moderate mitral annular calcification as judged by a previously published semi-quantitative echocardiographic score * Over 18 years of age * Able to use the semi-supine exercise bicycle * Should be able to give informed consent. Exclusion Criteria: * Oxygen dependent lung or cardiac disease * Moderate or greater aortic valvular disease * Moderate or greater mitral regurgitation * Reduced left ventricular ejection fraction, \<35% * Any diagnosed coronary disease * A resting mean gradient of ≥10 mmHg across the mitral valve.

What they're measuring

Change in mean mitral valve gradient from baseline to peak exercise in patients with Mitral Annular Calcification compared to controls.

Timeframe: Procedure day

Trial details

NCT IDNCT04093973

SponsorAlbert Einstein Healthcare Network

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-06-30

View on ClinicalTrials.gov More Mitral Annulus Calcification trials