Not Yet RecruitingNot Applicable

Closed Loop Ventilation With High Tidal Volumes and Safe Transpulmonary Pressure in COPD (COPD-SAFE)

Turkey (Türkiye)20 participantsStarted 2024-12

Plain-language summary

This study evaluates the safety and efficacy of high tidal volumes generated by "Adapted Support Ventilation (ASV) mode' in mechanically ventilated severe COPD patients. Every patient will be ventilated consecutively with ASV and Volume Control (VC) modes at 2 different levels of minute volume in 2 sets. ASV mode is expected to be safe measured by adequate inspiratory transpulmonary pressures and expected to be as effective as VC mode with lower intrinsic positive end expiratory pressure (iPEEP) levels.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Acute exacerbation of Chronic Obstructive Lung Disease * Being intubated for less than 24 hours * Not being planned to be extubated in 24 hours * Expiratory time constant (RCexp) more than \> 2.0 s Exclusion Criteria: * Restrictive lung pathologies * Impaired hemodynamic status * Esophageal pathologies * Bronchopleural fistula

What they're measuring

Transpulmonary inspiratory pressure (Ptinsp)

Timeframe: 30'th minute of each intervention arm

Trial details

NCT IDNCT04089111

SponsorIzmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02

Contact for this trial

Sami C Kirakli, MD

+905052352024 samicenk.kirakli@sbu.edu.tr

View on ClinicalTrials.gov More Chronic Obstructive Pulmonary Disease trials