CompletedNot Applicable

VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility

Germany125 participantsStarted 2019-09-01

Plain-language summary

This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially. The endogenous release of stress hormones will also be assayed in order to investigate their modifying effect on the hemodynamic reaction of the participants. The effect of fluid resuscitation on renal perfusion will also be assessed and the data compared with the release of cystatin C.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * mean arterial pressure \<65 mm Hg and/or * blood lactate \>2 mmol/l and/or * mottling or capillary refill \>3 seconds and/or * oliguria and * critical care decision for testing fluid responsiveness Exclusion Criteria: * cardiopulmonary resuscitation * uncontrolled bleeding * irreversible brain damage * pregnancy and lactation * Age under 18 years

What they're measuring

Changes in blood pressure under PLR vs. MVC

Timeframe: immediately at the end of the MVC

Trial details

NCT IDNCT04089098

SponsorUniversity of Leipzig

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-07-31

View on ClinicalTrials.gov More Hemodynamic Instability trials