CompletedNot Applicable

Evolution of Menstruation

France21 participantsStarted 2020-10-27

Plain-language summary

This study examines gene expression and gene regulation in the uterine lining during menses in women, for evolutionary comparison with other primates which do or do not menstruate. Samples will be obtained by non-invasive collection of menstrual fluid from healthy donors.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * having regular periods * being comfortable using silicone menstrual hygiene devices ("cup") * having giving consent in writing Exclusion Criteria: * use of an internal contraception method (hormone or non-hormone based) during or within three months before the study * pregnancy during or within three months before the study * amenorrhea (absent periods) during or within three months before the study * gynaecological intervention or surgery within three months before the study * hormonal treatment during or within three months before the study * absence of written consent * breastfeeding * medical treatment during the study * low (\< 18.5) or high (\> 30) body mass index (BMI)

What they're measuring

Gene expression levels measured by RNA-seq

Timeframe: Average to study completion 30 months

Active regulatory elements profiled by ATAC-seq

Timeframe: Average to study completion 30 months

Trial details

NCT IDNCT04085835

SponsorInstitut National de la Santé Et de la Recherche Médicale, France

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2025-04-27

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