Effects of Continuous Treatment With Rifaximin and Probiotics on the Gut Microbiota of Patients With IBS-D

Inclusion Criteria: * 18-75 years old; * in line with the diagnostic criteria of diarrhea-type irritable bowel syndrome Roman IV； * blood routine, blood biochemistry, stool examination and colonoscopy within 2 years are no problem; * no intestinal warning symptoms Exclusion Criteria: * suffering from severe heart, lung, liver, kidney, nervous system diseases; * suffering from mental disorders caused by schizophrenia, brain organic and physical diseases; * suffering from other diseases that may affect intestinal function (such as diabetes, thyroid disease); * History of previous abdominal surgery (excluding history of cholecystectomy or appendectomy); * pregnant or lactating women; * have undergone colonoscopy in the past month or accept other bowel preparation operations; * In the past 1 month, have used antibiotics, antidiarrheal agents, intestinal flora regulation, Chinese medicine and other drugs; * have participated in other dietary treatments; * understand communication barriers, unable to communicate