CompletedNot Applicable

A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock

China590 participantsStarted 2019-09-21

Plain-language summary

The objectives of this study are to determine whether Continuous Renal Replacement Therapy (CRRT) with oXiris in patients with septic shock would improve clinical outcomes such as the sepsis-related organ failure assessment (SOFA) , hemodynamic, mortality compared CRRT with conventional membrane.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \>18 Years * Treated by CRRT using oXiris or conventional membrane * SOFA cardiovascular Score ≥ 3 * Septic shock due to abdominal or pneumonia( Gram-negative bacterial infection or suspected GNB infection) * Written informed consent Exclusion Criteria: * Chronic Kidney Disease * Renal replacement therapy (RRT) in the last 30 days * Pregnancy * Immunosuppressive treatment or steroids (prednisone \> 0.5 mg/kg/day or equivalent). * Autoimmune disorder. * Transplant receptor. * Inclusion in other ongoing studies within the last 30 days. * Coexisting illness with a high probability of death

What they're measuring

28-day mortality

Timeframe: 28 days

The Sepsis-related Organ Failure Assessment(SOFA) cardiovascular Scores at 72 hours

Timeframe: 72 hours after Continuous Renal Replacement Therapy initiation

Trial details

NCT IDNCT04073771

SponsorSoutheast University, China

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-06-30

View on ClinicalTrials.gov More Acute Kidney Injury Due to Sepsis (Disorder) trials