CompletedNot Applicable

A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock

China590 participantsStarted 2019-09-21

Plain-language summary

The objectives of this study are to determine whether Continuous Renal Replacement Therapy (CRRT) with oXiris in patients with septic shock would improve clinical outcomes such as the sepsis-related organ failure assessment (SOFA) , hemodynamic, mortality compared CRRT with conventional membrane.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \>18 Years * Treated by CRRT using oXiris or conventional membrane * SOFA cardiovascular Score ≥ 3 * Septic shock due to abdominal or pneumonia( Gram-negative bacterial infection or suspected GNB infection) * Written informed consent Exclusion Criteria: * Chronic Kidney Disease * Renal replacement therapy (RRT) in the last 30 days * Pregnancy * Immunosuppressive treatment or steroids (prednisone \> 0.5 mg/kg/day or equivalent). * Autoimmune disorder. * Transplant receptor. * Inclusion in other ongoing studies within the last 30 days. * Coexisting illness with a high probability of death

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

28-day mortality

Timeframe: 28 days

The Sepsis-related Organ Failure Assessment(SOFA) cardiovascular Scores at 72 hours

Timeframe: 72 hours after Continuous Renal Replacement Therapy initiation

Trial details

NCT IDNCT04073771

SponsorSoutheast University, China

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-06-30

View on ClinicalTrials.gov More Acute Kidney Injury Due to Sepsis (Disorder) trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.