UnknownPhase 3

Norepinephrine and Phenylephrine, Which Better for Elderly?

China100 participantsStarted 2019-10-06

Plain-language summary

this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative hypotension, and to find the safest and most effective vasopressor for elderly.

Who can participate

Age range60 Years – 95 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * radical resection of colorectal or gastric cancers, * age over 65 years old, * surgical time longer than 2hours, * the American Society of Anesthesiologists(ASA) classification of II or III Exclusion Criteria: * history of severe cardiovascular diseases, * history of severe liver and kidney diseases, * evidence of arrhythmia on EKG, * use of positive end-expiratory pressure (PEEP) during mechanical ventilation; * conditions with relative contraindication for arterial catheterization

What they're measuring

hemodynamics- (CO)cardiac output

Timeframe: change from patient enters the operating room to end of operation, assessed up to the whole operation

Tissue perfusion and oxygenation-(DO2) Oxygen delivery;

Timeframe: change from beginning of operation to end of operation, assessed up to the whole operation

Tissue perfusion and oxygenation-(VO2)Oxygen consumption;

Timeframe: change from beginning of operation to end of operation, assessed up to the whole operation

Trial details

NCT IDNCT04067817

SponsorThe Second Affiliated Hospital of Dalian Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-30

Contact for this trial

xiao z yang, MD,PHD

17709873399 xiaozhaoy2012@163.com

View on ClinicalTrials.gov More Hypotension trials