Mandibular Furcation III Regeneration (FURC-III-REGEN)

Inclusion Criteria: * Subject must be ≥ 20 years * Subject must have periodontal disease as determined by the World Workshop 2017 criteria * Subjects must be undergoing periodontal treatment or follow-up and present 1 or more pair of bilateral mandibular molars affected by furcation involvement grade II with PPD \>4 mm, and the furcation fornix must be below a tangential line from the distal to mesial interproximal crestal bone level * Competent to give consent Exclusion Criteria: The following must not be present at the time of enrolment; * Previous radiotherapy to the jaws, current use of chemotherapy, systemic long-term corticosteroid treatment * Present or past use of bisphosphonate treatment * Pregnant or nursing subjects * Patients classified as \> class 2 according to the ASA (American Society of Anesthesiologists) physical status classification * Previous surgical therapy of included furcation defects * Inability to comprehend and respond to the quality of life questionnaire * Dental restorations or prosthesis involving the furcation area * Root fractures or suspected infractions * Caries lesions in the furcation area * No systemic antibiotic treatment within 3 months prior to intervention