Craniomaxillofacial and Upper Extremity Allotransplantation

Inclusion Criteria: * Signed and dated all required Institutional Review Board (IRB) approved consent forms. * Male or female recipient between the ages of 18-64 years. Recipients do not need to be of the same sex as the donor. * Facial composite tissue defect requiring facial transplantation as determined by the treating Plastic and Reconstructive Surgeon. Inclusive facial functional subunit tissue loss. Including but not limited to irreparable peri-oral, peri-orbital, and peri-nasal damage. * Missing part of one or both hands and forearms. * Must be HIV negative at the time of transplant. * Crossmatch is negative at the time of transplant. * Patient has been encouraged to seek a second opinion from a Plastic Surgeon with specialized focus in facial reconstruction. * Patient has been encouraged to seek a second opinion from a Plastic Surgeon with specialized focus in upper extremity reconstruction. * Willingness to participate in ongoing psychiatric, psychological and social work evaluations prior to and post-transplant surgery. * The subject is able to complete pre-transplant examination and screening procedures. * Patient has been approved by Patient Selection Committee for placement on the recipient waiting list. * The subject is willing to continue immunosuppression regimen as directed by treating physician. * Subject is willing and able to return to follow-up visits as described in treatment plan. * Subjects must have autogenous tissue options available for reconstruct…