CompletedNot Applicable

Gastro-intestinal and Hormonal Responses to Systemic Inflammatory Disease

Denmark8 participantsStarted 2019-06-17

Plain-language summary

The aim of this study is to describe hormonal responses and changes of the gastrointestinal (GI) tract during healthy and catabolic inflammatory conditions. Participants will receive isocaloric, isonitrogenous beverages of either whey or 3-OHB+whey in a randomized crossover design during either healthy (overnight fast) or catabolic conditions (inflammation/endotoxemia + 36 h fast and bed rest).

Who can participate

Age range20 Years – 40 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Between 20-40 years of age * Body mass index between 20-30 kg/m\^2 * Healthy * Oral and written consent forms obtained prior to study day Exclusion Criteria: * Recent immobilization of an extremity that is not fully rehabilitated * Lactose, lidocain or rubber allergies * Current disease * Use of anabolic steroids * Smoking Former major abdominal surgery (Or current problems with the GI tract) \>10 hours of exercise/weak Present ketogenic diets or high-protein diets Blood doner that does not want to discontinue blood donations until study completion Pending MR scan

What they're measuring

Difference in total gastro-intestinal transit time (healthy vs catabolic conditions)

Timeframe: Measured from intake of the Smartpill (together with the bolus of the protein beverages at t=210) until excretion with faeces (expected time frame: 2-5 days))

Trial details

NCT IDNCT04056286

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-23

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