WithdrawnNot Applicable

Lipodystrophy and Fat Metabolism During Exercise

Stopped: ethical and governance issues not resolved

United Kingdom0Started 2019-09-01

Plain-language summary

Mandibular dysplasia with deafness and progeroid features (MDP) syndrome is a rare genetic metabolic disorder that causes lipodystrophy: the inability of the body to store subcutaneous adipose tissue (fat under the skin). This creates a unique scenario where any ingested fat is diverted to the abdomen and liver, often leading to diabetes. The investigators have an opportunity to study an individual with MDP who has competed in and won national para-cycling championships and is able to prevent/control his diabetes by regular bicycle training. He has approached us for advice on nutritional strategies to improve his cycling performance, and insight into how he uses fat during exercise. The investigators also wish to study a moderately-trained cyclist with Familial partial lipodystrophy (FPL). Those with FPL show a different pattern of lipodystrophy than those with MDP, allowing us to further increase the investigator's understanding of fat utilisation in those with lipodystrophy during exercise. The investigators know how subcutaneous fat is used during exercise, and how duration, nutrition, carbohydrate availability, and exercise intensity can affect this. The investigators aim to investigate these processes during exercise in MDP and FPL. This will potentially provide nutrition and performance advice to the individuals, and insight on fat use in lipodystrophy and diabetes.

Who can participate

Age range18 Years – 35 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

SUBJECT WITH FPL Inclusion: • Already known to researchers. Male, 29 years old. CONTROL SUBJECT 1 Inclusion: * Highly trained, elite-level cyclist (VO2max \> 80 ml/kg/min) * Registered with, and racing under the jurisdiction of, British Cycling * \~\< 10% of body fat * Male * 18 - 35 years old Exclusion: * Any diagnosed metabolic impairment, as this may affect normal metabolism. * Any diagnosed cardiovascular disease or hypertension to avoid any complications associated with heavy exercise. * Chronic use of any prescribed or over-the-counter pharmaceuticals. CONTROL SUBJECT 2 Inclusion: * Recreationally active, preferably with experience of cycling training. * Similar (± 5 ml⋅kg-1⋅min-1) VO2max¬ to that of the participant with MDP Exclusion: * Any diagnosed metabolic impairment, as this may affect normal metabolism. * Any diagnosed cardiovascular disease or hypertension to avoid any complications associated with heavy exercise. * Chronic use of any prescribed or over-the-counter pharmaceuticals. SUBJECT WITH FPL Inclusion: * Recreationally active, preferably with experience of cycling training. * Similar (± 5 ml⋅kg-1⋅min-1) VO2max¬ to that of the participant with MDP * Diagnosis with FPL Exclusion: * Female * Any diagnosed cardiovascular disease or hypertension to avoid any complications associated with heavy exercise.

What they're measuring

Substrate utilisation

Timeframe: Throughout the 60 minute cycle

Trial details

NCT IDNCT04056000

SponsorUniversity of Exeter

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-31