CompletedPhase 4

Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients

United States19 participantsStarted 2019-11-30

Plain-language summary

This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* Patients scheduled to undergo liver transplantation * Patients able to read and understand consent document (if patient is unable to provide an informed consent, the Legally Authorized Representative will be ask to consent on behalf of the patient). * SVR lower than 500 dynes-sec/cm-5 intraoperatively (this criterion must be met after consent intraoperatively)

What they're measuring

Systemic Vascular Resistance (SVR)

Timeframe: 15, 30, 60, 90 and 120 minutes after initiation of treatment

Systolic Blood Pressure

Timeframe: 15, 30, 60, 90 and 120 minutes after initiation of treatment

Diastolic Blood Pressure

Timeframe: 15, 30, 60, 90 and 120 minutes after initiation of treatment

Vasopressin

Timeframe: 15, 30, 60, 90 and 120 minutes after initiation of treatment

Trial details

NCT IDNCT04054999

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-27

Results submitted2024-05-28

View on ClinicalTrials.gov More Vasoplegic Syndrome trials