Fruits and vegetables are beneficial for patients with metabolic syndrome, a condition characterized by the coexistence of various risk factors (obesity, hypertension, hypercholesterolemia, insulin resistance) that predispose to cardiovascular disease and diabetes. Diets such as the Mediterranean diet, rich in flavonoids and polyphenolic compounds can exert a high anti-inflammatory, antithrombotic and antiproliferative action. Several studies have shown that grape polyphenols exert a crucial protective action against the onset of cardiovascular, neurodegenerative, and cancer diseases. On the other hand, little information is available on the health effects deriving from the consumption of table grapes on cell membranes lipidomic profile. On this basis, the aim of this study is the evaluation of possible changes in lipidomic profile and plasma antioxidant activity induced by a diet enriched with table grape polyphenols.
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Changes in serum concentrations (mg/dL) of cholesterol, triglycerides, glucose
Timeframe: Before the start of the study (time 0), after four weeks (time 1) and after eight weeks (time 2)
Changes in blood concentration of fatty acids (stearic acid, oleic acid, arachidonic acid, eicosaepentanoic acid) expressed as percentage (%)
Timeframe: Before the start of the study (time 0) and after eight weeks (time 2)
Changes in serum concentration of single subfractions of LDL (expressed as mg/dL)
Timeframe: Before the start of the study (time 0) and after eight weeks (time 2)