Active — Not RecruitingNot Applicable

Dietary Oxalate and Innate Immunity in Kidney Stone Disease

United States20 participantsStarted 2021-03-05

Plain-language summary

This study will test whether oxalate stimulates urinary crystals and impacts the immune system in healthy subjects using two controlled diets (low and high oxalate).

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy subjects (men and women) between the ages of 18 and 60 years of age * No calcium oxalate kidney stones or other medical conditions * Normal comprehensive metabolic panel (CMP) * Non tobacco users * Not pregnant * BMI between 20-30 kg/m2 * Willing to abstain from vigorous exercise and vitamins/supplements during the study * Willing to consume only provided diets, accurately collect 24-hour urine samples, and have blood drawn Exclusion Criteria: * Inability to sign and read the informed consent * Any medical, psychiatric, or social conditions that would prohibit participants from abiding by the study requirements * Physician refusal * Pregnant women * Active medical problems * History of kidney stones or any medical condition that could influence absorption or excretion of oxalate * Tobacco users * Taking medications or dietary supplements * BMI \>30 or \<20

What they're measuring

Change in Urinary Oxalate

Timeframe: Days 3-4 and 13-14

Change in Crystalluria

Timeframe: Days 3-4 and 13-14

Change in Monocyte Cellular Energetics and Mitochondrial Function

Timeframe: Days 1, 4, 11, and 14

Change in Monocyte Subtypes

Timeframe: Days 1, 4, 11, and 14

Change in Monocyte Transcriptomics

Timeframe: Days 1, 4, 11, and 14

Trial details

NCT IDNCT04051346

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-01

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