The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period. This endocrine manipulation paradigm, which the investigators have shown provokes irritability in past studies, will be used to examine the neurocircuitry underlying irritability under baseline and hormone challenge conditions among women who are hormone sensitive (HS+; n=15) and non-hormone sensitive (HS-; n=15). The long-term goal of this research is to advance understanding of the neural systems underlying both the triggering of and susceptibility to irritability in women. The objective of the current project is to examine whether HS+ show differences in the behavioral activation system relative to HS- under baseline and hormone challenge conditions using functional magnetic resonance imaging (fMRI) and behavioral tests.
Age range
22 Years – 45 Years
Sex
FEMALE
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Mean Threat Processing Bias During Visual Dot-probe Paradigm Over Time
Timeframe: up to 6 weeks
Mean Right Amygdala-medial Prefrontal Cortex BOLD Connectivity During Implicit Emotion Face Processing Task Over Time
Timeframe: up to 6 weeks
Mean Left Amygdala-medial Prefrontal Cortex BOLD Connectivity During Implicit Emotion Face Processing Task Over Time
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Mean Reactive Aggression During Hormone Addback Over Time
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Mean BOLD Activation of the Right Amygdala During the Affective Posner Task Over Time
Timeframe: up to 6 weeks
Mean BOLD Activation of the Left Amygdala During the Affective Posner Task Over Time
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Mean BOLD Activation of the Right Caudate During the Affective Posner Task Over Time
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Mean BOLD Activation of the Left Caudate During the Affective Posner Task Over Time
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Mean BOLD Activation of the Right Putamen During the Affective Posner Task Over Time
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Mean BOLD Activation of the Left Putamen During the Affective Posner Task Over Time
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Mean BOLD Activation of the Right Nucleus Accumbens During the Affective Posner Task Over Time
Timeframe: up to 6 weeks
Mean BOLD Activation of the Left Nucleus Accumbens During the Affective Posner Task Over Time
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