CompletedNot Applicable

Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults

United States141 participantsStarted 2021-07-01

Plain-language summary

The central hypothesis is that higher protein intake and a neutralizing alkaline salt supplement will improve muscle performance and mass, compared to their respective placebos, in older men and postmenopausal women.

Who can participate

Age range65 Years

SexALL

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Inclusion criteria

✓. ability to sign informed consent form
✓. ambulatory community-dwelling men and women
✓. age 65 years and over
✓. habitual dietary intake of protein of ≤0.8 g/kg/d
✓. underactive
✓. estimated glomerular filtration rate ≥ 50 ml/min/1.73 m2

Exclusion criteria

✕. participation in a diet or intensive exercise program during the study
✕. vegetarian (no animal protein)
✕. oral glucocorticoid use for \> 10 days in the last 3 months
✕. anabolic and gonadal hormones in the last 6 months
✕. Tamoxifen/raloxifene in the last 6 months
✕. regular use of alkali-producing antacids (\> 3 times per week)
✕. potassium-containing supplements or products
✕. non-steroidal anti-inflammatory medications \>3 times per week

What they're measuring

Double Leg Press Peak Power at 70%

Timeframe: 24 weeks

Trial details

NCT IDNCT04048616

SponsorTufts University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-21

Results submitted2025-04-01

View on ClinicalTrials.gov More Age-Related Sarcopenia trials