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Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

Hong Kong182 participantsStarted 2019-05-15

Plain-language summary

This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in patients with idiopathic REM Sleep Behavior Disorder (iRBD) and healthy controls.

Who can participate

Age range50 Years

SexALL

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Inclusion criteria

✓. Fulfilling the diagnostic criteria for iRBD. As patients with iRBD were recruited during a long period, the diagnosis of RBD was based on ICSD and ICSD-2 (before 2014), and ICSD-3 (2014 and thereafter) criteria. The diagnosis for all patients were confirmed by video-PSG. In summary, patient diagnosed with RBD should present excessive EMG activity during REM sleep on video-PSG assessment and report a history of repeated dream enactment behaviors;
✓. Having neurocognitive test and neurological examination since 2008;
✓. Free of neurodegenerative diseases at the last visit.
✓. Age- and sex- matched with patients with iRBD;
✓. Free of narcolepsy and other neurological diseases;
✓. Without any RBD features as confirmed by both clinical history and video-PSG;
✓. Without neurodegenerative diseases;
✓. Having neurocognitive test and neurological examination at baseline.

Exclusion criteria

✕. Patients with narcolepsy;
✕. Patients with known neurodegenerative diseases;
✕. Pseudo-RBD (e.g., RBD symptoms were eliminated after severe obstructive sleep apnea had treated with continuous positive airway pressure therapy.);
✕. Early-onset RBD (e.g., before the age of 50 years old) which might have a different pathogenesis from iRBD.

What they're measuring

The overall conversion rate of iRBD to neurodegenerative diseases

Timeframe: Changes from baseline to 7 year follow up

Trial details

NCT IDNCT04048603

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-03-31

Contact for this trial

Jihui Zhang, PhD

(852)39197647 jihui.zhang@cuhk.edu.hk

View on ClinicalTrials.gov More REM Sleep Behavior Disorder trials