CompletedNot Applicable

The PrEPARE Project: Prevention, Empowering, and Protecting Young Women in South Africa

South Africa802 participantsStarted 2019-04-04

Plain-language summary

The project seeks to determine whether implementing a multilevel, woman-focused intervention, the Young Women's Health CoOp (YWHC), for pre-exposure prophylaxis (PrEP) readiness, uptake, and adherence is a viable complement to the HIV prevention plan for the Government of South Africa. Specifically, this project aims to: increase uptake, of sexual and reproductive health (SRH) services and readiness and uptake of PrEP among adolescent girls and young women (AGYW) aged 16 to 24 who engage in high-risk sexual behaviors; and reduce their barriers to accessing SRH services by addressing and reducing stigma and discrimination (S\&D) in clinics.

Who can participate

Age range16 Years – 24 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * HIV negative * identify as female; * aged 16-24; * have had condomless sex in the past 3 months with a male partner; * not be currently pregnant and not want to get pregnant for the next year; * interested in taking PrEP; * not having previously participated in the formative phase of the study; * have not previously and not currently participating in any other PrEP-related demonstration project or research study; * not previously or not currently participating in any other HIV study in Tshwane; * lives in one of the target communities; * not on multidrug-resistant tuberculosis (MDR-TB) treatment; * intends to stay in the Tshwane district for the next 12 months; * agrees to provide contact information; * be willing to undergo rapid HIV testing; * be willing to undergo pregnancy testing. Exclusion Criteria: \-

What they're measuring

Health Clinic-Level Outcome: Level of Health Clinic Stigma and Discrimination

Timeframe: Baseline

Health Clinic-Level Outcome: Level of Health Clinic Stigma and Discrimination

Timeframe: 4 months

Health Clinic-Level Outcome: Level of Health Clinic Stigma and Discrimination

Timeframe: 8 months

Health Clinic-Level Outcome: The Number of AGYW who Uptake HIV and SRH services, including PrEP

Timeframe: Baseline

Health Clinic-Level Outcome: The Number of AGYW who Uptake HIV and SRH services, including PrEP

Timeframe: 4 months

Health Clinic-Level Outcome: The Number of AGYW who Uptake HIV and SRH services, including PrEP

Timeframe: 8 months

AGYW Participant Self-Report: The Level of PrEP Readiness among AGYW

Timeframe: Baseline

AGYW Participant Self-Report: The Level of PrEP Readiness among AGYW

Trial details

NCT IDNCT04048551

SponsorRTI International

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-23

View on ClinicalTrials.gov More HIV Prevention trials

Plain-language summary

Who can participate

Age range16 Years – 24 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Health Clinic-Level Outcome: Level of Health Clinic Stigma and Discrimination

Timeframe: Baseline

Health Clinic-Level Outcome: Level of Health Clinic Stigma and Discrimination

Timeframe: 4 months

Health Clinic-Level Outcome: Level of Health Clinic Stigma and Discrimination

Timeframe: 8 months

Health Clinic-Level Outcome: The Number of AGYW who Uptake HIV and SRH services, including PrEP

Timeframe: Baseline

Health Clinic-Level Outcome: The Number of AGYW who Uptake HIV and SRH services, including PrEP

Timeframe: 4 months

Health Clinic-Level Outcome: The Number of AGYW who Uptake HIV and SRH services, including PrEP

Timeframe: 8 months

AGYW Participant Self-Report: The Level of PrEP Readiness among AGYW

Timeframe: Baseline

AGYW Participant Self-Report: The Level of PrEP Readiness among AGYW