WithdrawnNot Applicable

Detecting Probable Alzheimer's Disease From Speech Using Linguistical Analysis

Stopped: Unsuccessful in recruiting participants for that study because we needed subjects who had performed Amyloid PET imaging in the last year

United States0Started 2018-08-13

Plain-language summary

The object of this study is to investigate the use of linguistic deficits from speech samples for the early detection of Mild Cognitive Impairment and probable Alzheimer's disease. It will also evaluate whether the result of the Amyloid PET scan would confirm the effectiveness of a less expensive and less intrusive diagnostic technique through speech

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants who have undergone the Mini Mental State Examination (MMSE). * Participants who have undergone Amyloid PET scan with a diagnosis of having the Amyloid plaques or not. * Participants with moderate or fluent English speaking ability. Exclusion Criteria: * Participants who cannot speak as the data collection process needs to obtain speech samples. * Participants who are severely demented or at a very late stage of Alzheimer's disease. * Participants with stroke. * Participants who report a history of other neurodegenerative disorders than MCI and AD. * Participants with chronic vision impairment or who cannot see with the aid of corrective glasses. * Participants who cannot speak English. * A participant who have been diagnosed with HIV/AIDS as this may have a cognitive effect on its own.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Analysis of speech audio recording describing the "Cookie-Thief Image" using proposed computational model designed by PI for determination of Alzheimer's disease

Timeframe: through study completion, an average of 1 year

Trial details

NCT IDNCT04041895

SponsorEast Tennessee State University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-08

View on ClinicalTrials.gov More Alzheimer Disease trials

Plain-language summary

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.