Active — Not RecruitingPhase 2

Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis

United States200 participantsStarted 2019-07-25

Plain-language summary

The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated appendicitis compared to suction without irrigation. This will be the first prospective study to compare these two options in pediatric PA.

Who can participate

Age range0 Years – 18 Years

SexALL

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Inclusion criteria

✓. Male or female, age 18 years or younger
✓. Scheduled to undergo laparoscopic appendectomy
✓. Preoperative or intra-operative diagnosis of perforated appendicitis (PA).
✓. Willingness to undergo treatments, provide written informed consent, and participate in follow-up.

Exclusion criteria

✕. Male or female older than 18 years of age
✕. Declined to undergo laparoscopic appendectomy
✕. Not willing to provide written informed consent or undergo randomization of treatment
✕. Pregnancy

What they're measuring

wound complications

Timeframe: 30 days

Trial details

NCT IDNCT04039750

SponsorPrisma Health-Upstate

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

View on ClinicalTrials.gov More Perforated Appendicitis trials