CompletedNot Applicable

Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia

Taiwan36 participantsStarted 2018-10-24

Plain-language summary

The study aimed to investigate the effects of high-definition transcranial random noise stimulation over bilateral prefrontal cortex on psychopathological symptoms, other clinical outcomes, autonomic functioning ,and brain oscillatory activity in schizophrenia patients.

Who can participate

Age range20 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Eligible participants aged 20-65 with DSM-V-defined schizophrenia or schizoaffective disorder.
✓. Duration of illness ≧ 1 year.
✓. Being on an adequate therapeutic dose of antipsychotics for at least 8 weeks prior to enrolment.
✓. Positive and Negative Syndrome Scale (PANSS scale) total score \< 120 (at both screening and baseline).
✓. Agreement to participate in the study and provide the written informed consent.

Exclusion criteria

✕. Having current psychiatric comorbidity or active substance use disorder, in exception to caffeine and/or tobacco.
✕. Having a history of seizures.
✕. Having contraindications for transcranial electrical stimulation or transcranial magnetic stimulation, e.g., implanted brain medical devices or metal in the head.
✕. Having a history of intracranial neoplasms or surgery, or a history of severe head injuries or cerebrovascular diseases.
✕. Pregnancy or breastfeeding at enrollment.

What they're measuring

Changes from baseline negative dimension score of Positive and Negative Syndrome Scale (PANSS) at the timepoint immediately after HD hf-tRNS, at one-week and one-month follow-ups.

Timeframe: One month

Trial details

NCT IDNCT04038788

SponsorTri-Service General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-05-17

View on ClinicalTrials.gov More Schizophrenia trials