CompletedNot Applicable

Echocardiographic Changes After 3-hydroxy Butyrate+Whey Intake

Denmark8 participantsStarted 2019-06-17

Plain-language summary

This study evaluates the cardiovascular effects of adding the ketone body 3-hydroxy butyrate (3-OHB) to whey protein during human endotoxemia. Further, this study compares cardiovascular changes during healthy and catabolic conditions. Participants will receive isocaloric, isonitrogenous beverages of either whey or 3-OHB+whey in a randomized crossover design during either healthy (overnight fast) or catabolic conditions (inflammation/endotoxemia + 36 h fast and bed rest).

Who can participate

Age range20 Years – 40 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Between 20-40 years of age * Body mass index between 20-30 kg/m\^2 * Healthy * Oral and written consent forms obtained prior to study day Exclusion Criteria: * Recent immobilization of an extremity that is not fully rehabilitated * Lactose, lidocain or rubber allergies * Current disease * Use of anabolic steroids * Smoking * Former major abdominal surgery (Or current problems with the GI tract) •\>10 hours of exercise/weak * Present ketogenic diets or high-protein diets * Blood doner that does not want to discontinue blood donations until study completion * Pending MR scan

What they're measuring

Change in left ventricular outflow tract velocity time integral

Timeframe: Measured during the basal period and after 1.5 hours of intervention

Trial details

NCT IDNCT04037722

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-23

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