Active — Not RecruitingNot Applicable

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

United States230 participantsStarted 2019-07-26

Plain-language summary

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. We propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * EDS patients, clinically diagnosed hypermobile EDS based on 2017 criteria * EDS patients with genetically proven non-hypermobile EDS * Healthy participants, no EDS * Able and willing to provide informed consent Exclusion Criteria: * Known allergy to Lidocaine or Bupivacaine * Unable to provide informed consent

What they're measuring

Delta Pain Scores Lidocaine at 5 min

Timeframe: 5 minutes post-injection

Trial details

NCT IDNCT04036305

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-12-31

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