CompletedNot Applicable

Modification of Pavlovian and Instrumental Learning in Human Addiction

Germany80 participantsStarted 2019-10-01

Plain-language summary

The project aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders.

Who can participate

Age range18 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Men and women aged 16-32 years, 33-49 years, and aged 50-65 years
✓. Mild, moderate to heavy alcohol-use disorder (AUD) according to DSM-5 criteria (mild: 2-3 AUD criteria; moderate: 4-5 AUD criteria; heavy: 6 or more AUD criteria); not clinically requiring detoxification (as confirmed by an independent board-certified psychiatrist); AUD patients can have mild to moderate cannabis use disorder as well as tobacco use disorder
✓. Ability to provide fully informed consent and to use self-rating scales
✓. Willingness to use an android phone
✓. Sufficient understanding of the German language

Exclusion criteria

✕. Lifetime history of DSM-5 bipolar disorder, schizophrenia or schizophrenia spectrum disorder, or substance dependence other than alcohol or nicotine or cannabis dependence. Severe alcohol and cannabis use disorder will be excluded.
✕. Current threshold DSM-5 diagnosis of major depressive disorder, or presence of suicidal intention
✕. History of severe head trauma or other severe central nervous system disorder (e.g., dementia, Parkinson's disease, multiple sclerosis)
✕. Pregnancy or nursing infants
✕. Current use of medications or drugs known to interact with the CNS within at least four half-life post last intake

What they're measuring

Blood Oxygen Level Dependent especially within the ventral striatum and the amygdala (fMRI)

Timeframe: 2 consecutive days

Rate of Pavlovian-to-instrumental-Transfer (instrumental responding, i.e.number of button presses, in dependence of Pavlovian Stimuli)

Timeframe: 2 consecutive days

Rate of goal-directed decision-making/habitual decision making

Timeframe: 2 consecutive days

Trial details

NCT IDNCT04032587

SponsorCharite University, Berlin, Germany

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-30

View on ClinicalTrials.gov More Healthy trials

Who can participate

Age range18 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Men and women aged 16-32 years, 33-49 years, and aged 50-65 years
✓. Mild, moderate to heavy alcohol-use disorder (AUD) according to DSM-5 criteria (mild: 2-3 AUD criteria; moderate: 4-5 AUD criteria; heavy: 6 or more AUD criteria); not clinically requiring detoxification (as confirmed by an independent board-certified psychiatrist); AUD patients can have mild to moderate cannabis use disorder as well as tobacco use disorder
✓. Ability to provide fully informed consent and to use self-rating scales
✓. Willingness to use an android phone
✓. Sufficient understanding of the German language

Exclusion criteria

✕. Lifetime history of DSM-5 bipolar disorder, schizophrenia or schizophrenia spectrum disorder, or substance dependence other than alcohol or nicotine or cannabis dependence. Severe alcohol and cannabis use disorder will be excluded.
✕. Current threshold DSM-5 diagnosis of major depressive disorder, or presence of suicidal intention
✕. History of severe head trauma or other severe central nervous system disorder (e.g., dementia, Parkinson's disease, multiple sclerosis)
✕. Pregnancy or nursing infants
✕. Current use of medications or drugs known to interact with the CNS within at least four half-life post last intake

What they're measuring

Blood Oxygen Level Dependent especially within the ventral striatum and the amygdala (fMRI)

Timeframe: 2 consecutive days

Rate of Pavlovian-to-instrumental-Transfer (instrumental responding, i.e.number of button presses, in dependence of Pavlovian Stimuli)

Timeframe: 2 consecutive days

Rate of goal-directed decision-making/habitual decision making

Timeframe: 2 consecutive days