This will be a prospective study to determine the association between specific genotypes, epigenetics, behavioral, social and biological factors, with the phenotypes, defined by pain perception, postoperative pain, analgesic effects, side effects to perioperative analgesics, chronic postoperative pain, and gene expression in patients following pectus excavatum repair.
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Pain score trajectory
Timeframe: 1 year
Changes in self-reported psychosocial scores (including anxiety, pain, coping, physical limitation, etc.)
Timeframe: 1 year
Changes in heart rate variability
Timeframe: 8 weeks
Changes in mean amplitude values for lower, upper, and entire alpha frequency bands by group (intervention/no intervention) and time (pre-surgery/post-surgery)
Timeframe: 8 weeks
Changes in evoked response potentials (ERPs) during meditation and experimental pain tasks
Timeframe: 8 weeks
Changes in sleep efficiency/duration (actigraphy) and self-reported sleep quality
Timeframe: 8 weeks
Incidence of side-effect measures
Timeframe: 72 hours postoperatively