RecruitingEarly Phase 1

Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

United States120 participantsStarted 2020-09-02

Plain-language summary

The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.

Who can participate

Age range22 Years – 33 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Singleton birth * Born at less than 34 weeks gestational age (preterm cohort) * Born at greater than 36 weeks gestational age (term cohort) Exclusion Criteria: * Twin birth * Congenital anomalies or genetic syndromes * Currently pregnant or breast feeding * Subject-reported history of hypertension * Current use of antihypertensive medications * Active cancer * Chronic kidney disease * Heart failure * Liver failure

What they're measuring

Proportion with salt sensitivity of blood pressure at baseline via ABPM

Timeframe: Day 7 to 14

Proportion with salt sensitivity of blood pressure after allopurinol via ABPM

Timeframe: Day 49 to 56

Salt sensitivity index at baseline

Timeframe: Day 7 to 14

Salt sensitivity index after allopurinol

Timeframe: Day 49 to 56

Proportion with salt sensitivity of blood pressure at baseline via casual blood pressure

Timeframe: Day 7 to 14

Proportion with salt sensitivity of blood pressure after allopurinol via casual blood pressure

Timeframe: Day 49 to 56

High blood pressure at baseline via ABPM

Timeframe: Day 0

Hypertension at baseline via ABPM

Timeframe: Day 7

Trial details

NCT IDNCT04026776

SponsorWake Forest University Health Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06

Contact for this trial

Hossam Shaltout, PhD

336-716-1251 hshaltou@wakehealth.edu

View on ClinicalTrials.gov More Salt; Excess trials