This is an observational study aiming to prospectively define the rate of occurrence, natural history and progression of cardiac dysfunction in adults, and to identify the patients at high risk of developing cardiovascular events. The study enrolls patients prior to infusion with CART cell therapy and follows them with serial echocardiography, cardiac biomarkers, clinical data, and quality of life questionnaire.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* At least 18 years of age
* Diagnosed with CD19+ malignancy undergoing treatment with CART cells
Exclusion Criteria:
* Unable to provide informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial has already been completed and was measuring how often CAR-T cell therapy causes left ventricular dysfunction, has my doctor seen the results, and what do they mean for someone in my situation who might be considering CAR-T treatment?
2Given that this study focused specifically on cardiotoxicity as a risk of CAR-T therapy, what heart monitoring would I need before, during, and after CAR-T treatment to watch for this kind of problem?
3If left ventricular dysfunction is a known cardiovascular risk with CAR-T cell therapy, does my current heart health make me more or less vulnerable to that side effect, and should I see a cardiologist before deciding on this treatment?
4Are there findings from this completed trial that might change how my care team would manage or prevent heart-related complications if I were to receive CAR-T therapy for my leukemia or lymphoma?
5Would standard treatments for my condition carry a lower cardiovascular risk than CAR-T therapy, and how does my doctor weigh that trade-off given what this kind of research has shown?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.