A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

Inclusion Criteria: * Patients with trauma involving two or less limbs where the continuity of a given peripheral nerve or nerves is unclear on presenting physical examination. * Closed soft tissue envelope obscuring direct observation of the continuity of the affected nerve. * Cognitive ability to report sensory and motor deficit during examination. * Able to complete dosing within four days (96 hours) of nerve injury diagnosis. * Able to provide informed consent * Eligible for standard of care plan of monitoring vs surgical exploration of the nerve. * Adults subject aged 18-90 * Known limb trauma which resulted in nerve injury (aim 1) or post-operative/post intervention nerve injury (aim 2). * Ability to give written informed consent. * Capable of safely undergoing electrodiagnostic testing (EDX). * Availability for all testing days and main trial day. Exclusion Criteria: * Not able to complete dosing within four days (96 hours) of nerve injury diagnosis * Distracting injury which prevents adequate examination. * Plan for surgical exploration of the nerve during the ensuing 48 hours. * Plan for surgical exploration of the nerve as part of another surgical procedure within 48 hours of evaluation. * Intoxication during examination or evidence of cognitive deficit that emerges during examination. * History of multiple sclerosis, stroke or any other diagnosed neurological disorder * History of hypersensitivity to AMPYRA® or 4-aminopyridine * Renal impairment based on calcula…