In vivo confocal microscopy (IVCM) has been used in clinical settings for more than 25 years, and is noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders. It enables morphological and quantitative analysis of ocular surface microstructure. \[1-3\] As the technology advances, new IVCM machine, Heidelberg Retinal Tomograph with Rostock Corneal Module (HRT-RCM), was developed. Hardware and software modifications and acquisition techniques continue to expand the applications of the HRT-RCM for quantitative in vivo corneal imaging at the cellular level. The new software can access the corneal nerve more accurate. Here the investigators proposed this Institutional Review Board (IRB) to collect healthy persons and cases of different systematic diseases as well as etiologies of ocular surface diseases.
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Confocal microscopy exam of sub-basal corneal nerve fibre density (NFD) by using the CCMetrics software
Timeframe: Baseline, 3 months and 6 months.
Confocal microscopy exam of sub-basal corneal nerve branch density (NBD) by using the CCMetrics software
Timeframe: Baseline, 3 months and 6 months.
Confocal microscopy exam of sub-basal corneal nerve fibre length (NFL) by using the CCMetrics software
Timeframe: Baseline, 3 months and 6 months.
Confocal microscopy exam of sub-basal corneal nerve fibre tortuosity (NFT) by using the CCMetrics software
Timeframe: Baseline, 3 months and 6 months.