CompletedNot Applicable

Positive End-expiratory Pressure Effects to Predict Fluid Responsiveness

France66 participantsStarted 2019-12-13

Plain-language summary

Volume expansion is one of the main treatments for shock. A test to predict the effectiveness of volume expansion prior to administration would avoid the need for excess treatment if it proves to be unnecessary.PEEP test would be an easy alternative to the tests used in current practice.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Coverage by a health insurance scheme * Patient under mechanical invasive ventilation (tracheal intubation) * PEEP level ≥10 cmH2O * Cardiac flow monitoring device in place by the PiCCO2 system (Pulsion Medical Systems, Feldkirch, Germany). * Ikorus urinary catheter in place * Decision by the doctors in charge of carrying out a passive leg raising test and / or a volume expansion Exclusion Criteria: * Pregnancy * Participation in another interventional study * Patients under the protection of justice * Thoracic drainage (preventing PEP changes from inducing intrathoracic and transpulmonary pressure changes from their hemodynamic effects).

What they're measuring

Ability of the PEP test to detect a preload-dependency condition.

Timeframe: At the end of the hospitalization in intensive care unit (1 month maximum)

Trial details

NCT IDNCT04023786

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-07-01

View on ClinicalTrials.gov More Mechanical Ventilation trials