CompletedNot Applicable

Motor Plasticity, Intermittent Hypoxia and Sleep Apnea

United States30 participantsStarted 2021-07-16

Plain-language summary

The purpose of this study is to learn about the effect of sleep apnea and low oxygen on muscle strength and lung function in people with chronic spinal cord injury.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age 18 or older,
✓. Chronic (≥ 1-year post-injury), non-progressive SCI,
✓. Asia Impairment Scale (AIS) C or D,
✓. Resting Saturated oxygen (SaO2) ≥ 95%,
✓. Cervical injury (C5-C8)

Exclusion criteria

✕. Currently hospitalized,
✕. Resting heart rate ≥120 Beats per minute (BPM),
✕. Resting systolic blood pressure \>180 mmHg,
✕. Resting diastolic Blood Pressure \>100 mmHg,
✕. Self-reported history of unstable angina or myocardial infarction within the previous month,
✕. OSA that is being treated with positive airway pressure therapy,
✕. Women who know or suspect they may be pregnant or who may become pregnant,
✕. Known underlying lung disease,

What they're measuring

The difference in Motor Function assessed via hand grip strength measured by maximum grip strength (MGS) between participants with moderate to severe OSA and without OSA.

Timeframe: Baseline

The difference in Motor Function assessed via hand grip strength measured by electromyographic (EMG) recordings between participants with moderate to severe OSA and without OSA.

Timeframe: Baseline

Trial details

NCT IDNCT04017767

SponsorUniversity of Miami

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-01

View on ClinicalTrials.gov More Sleep Apnea, Obstructive trials