UnknownNot Applicable

Probiotics Attenuate Postoperative Cognition Decline

China220 participantsStarted 2019-12-15

Plain-language summary

The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.

Who can participate

Age range

65 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. . Age is greater than or equal to 65 years old
. . Can communicate normally
. . Selective knee ankle, hip replacement or lumbar open reduction and internal fixation under general anesthesia
. . ASA graded at I-II level
. . Patient or family informed consent

Exclusion criteria

. . Have a brain disease, or have a history of brain disease
. .MMSE check of less than 24 points.
. . History of neurological and psychological disorders including AD, stroke, psychosis
. . Serious hearing or visual impairment
. . Preoperative systolic blood pressure \>190mmhg, or diastolic blood pressure \>100mmhg
. . The patient or family refuses

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Incidence of POCD 7days after surgery

Timeframe: The seventh day after surgery

Trial details

NCT IDNCT04017403

SponsorRenJi Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

Contact for this trial

tang ying, Bachelor

13918859887 421941497@qq.com

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