Application of a TBE-Vaccine in Obese Persons

main Inclusion Criteria: * willingness to sign written informed consent form * completed primary TBE immunization and at least 1 booster vaccination * participants of both sexes between 18 and 60 years of age main Exclusion Criteria: * age \< 18 and \> 60 years * BMI 25-30 * previous TBE infection * pregnancy or breast feeding * acute infection on day of inclusion (day 0) or at visit 5 (36 months), body temperature \> 37,9°C * concomitant medications: systemic cortison therapy, chemotherapy, immunotherapy (allergy) immunsuppressive therapy 4 weeks prior or during the study * administration of other vaccines 4 weeks before/after day 0 * planned surgery within 2 weeks before/after TBE booster * any contraindication to administration of FSME-Immun® vaccine according to manufacturer's instructions * malignant diseases within 5 years prior to the study * autoimmune diseases * kidney insufficiency, dialysis * drug addiction * plasma donor * receipt of blood transfusions or immunoglobulins within 3 months prior to study entry / within 3 months prior to visit 5 * Severe disease with hospitalization or surgery 3 months before or during the study * participation in a clinical trial simultaneously to visit 1-4 with receipt of vaccination and/or investigational product within one month before booster