RecruitingNot Applicable

Measurement Of NT-proBNP to Predict Outcomes in Surgery

United Kingdom200 participantsStarted 2019-09-05

Plain-language summary

The team is investigating whether N-terminal pro B-type natriuretic peptide (NT-proBNP) and other cardiac markers are useful for predicting outcomes for patients undergoing vascular surgery. By measuring NT-proBNP before and after surgery, the investigators may be able to determine which patients are at risk of an adverse outcome, such as a heart attack or death.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who are equal to or over 18 years old * Patients scheduled to undergo elective surgery for the following procedures: * Infrainguinal arterial reconstruction * Aortic aneurysm * Aorto-bifemoral bypass / or aortic endarterectomy * Femoro-popliteal bypass * Femoro-distal bypass * Femoral endarterectomy * Femoro-femoral crossover * Axillo-femoral bypass * Elective carotid surgery * Patients having either general or regional anaesthesia for their surgery Exclusion Criteria:- * Patients undergoing emergency surgery * Those who are unable or unwilling to give informed consent * Patients with unstable coronary syndromes (acute or recent MI with evidence of important ischemic risk by clinical symptoms or stress testing or unstable or severe angina pectoris) * Patients with decompensated heart failure (new onset shortness of breath and rales together with echocardiographic evidence of cardiac dysfunction or deterioration of chronic heart failure despite heart failure therapy) * Patients with chronic atrial fibrillation

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

NT-proBNP blood test measured on the day of (pre-) vascular surgery

Timeframe: 4 days

NT-proBNP blood test measured on the day 4 after (post-) vascular surgery

Timeframe: 4 days

Change in NT-proBNP peri-operatively

Timeframe: 4 days

Trial details

NCT IDNCT04014647

SponsorNorfolk and Norwich University Hospitals NHS Foundation Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-09-05

Contact for this trial

Emma Miler, MSc BSc Hons

+44(0)1603-286-932 emma.miler@nnuh.nhs.net

View on ClinicalTrials.gov More Vascular Surgical Procedure trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.