Although it is widely used, slow freezing can induce strong functional and nuclear spermatic alterations reducing the chances of pregnancy. The study objective is to determinate the effects of the combination of hypotaurine supplementation and spermatozoa selection by Density Gradient Centrifugation (DGC) on human sperm functions and DNA quality during a freezing-thawing cycle.
Age range
18 Years
Sex
MALE
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
chromatin packaging labelled using aniline blue and chromomycin A3
Timeframe: Day 0
DNA fragmentation using TUNEL assay
Timeframe: Day 0
DNA oxidation assessed by 8-OHdG immunodetections
Timeframe: Day 0
vacuoles presence in the spermatozoa head using Motile Sperm Organelle Morphology Examination (MSOME)
Timeframe: Day 0