Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

Inclusion Criteria: * Acute Traumatic Brain Injury (TBI) * Age 18-100 are eligible * Glasgow Coma Scale (GCS) 3-13 without continuous sedation at time of enrollment * Ability to enroll within 72 hours of injury * Hemorrhagic contusional injuries to frontal and/or temporal lobes. * Polytrauma including long bone fractures, blunt trauma, abdominal trauma or similar will be allowed * Penetrating TBI if continuous electroencephalography (cEEG) is feasible and survival for 2 years is feasible, recognizing that MRI may not be feasible with some forms of penetrating trauma Exclusion Criteria: * Low-affinity TSPO binding profile * Ages 17 years or younger * Patients with diffuse axonal injury in the absence of hemorrhagic contusions or skull fracture, and isolated epidural hemorrhages that improve after evacuation * No planned continuous EEG monitoring during injury day 1-7 * Inability to undergo MRI at 14 days (± 4 days) due to bullet, metal implant, or pacemaker * Pregnancy * Pre-existing Neurodegenerative Disorders * Pre-existing epilepsy/seizure disorder * Pre-existing dementia * Isolated anoxic brain injury * Incarceration present or pending * Devastating cervical spine injury