K0706 for Patients Diagnosed With Dementia With Lewy Bodies

Exclusion criteria

• . Medical history of liver or pancreatic disease, GI ulcers and Chron's disease, kidney, GI, or blood problems
• . Abnormal liver function defined as Aspartate aminotransferase ( AST) and/or Alanine aminotransferase (ALT) \> 100% the upper limit of the normal
• . Renal insufficiency as defined by a serum creatinine \> 1.5 times the upper limit of normal or proteinuria
• . History of Human immunodeficiency virus (HIV), clinically significant chronic hepatitis, or other active infection
• . Hypokalemia, hypomagnesaemia, or long QT syndrome- QTc≥471 ms or concomitant drugs known to prolong the QTc interval and history of any cardiovascular disease, including myocardial infarction or cardiac failure, angina, arrhythmia
• . History or presence of significant cardiac conditions including: cardiovascular or cerebrovascular event (e.g. myocardial infarction, unstable angina, or stroke), congestive heart failure, first, second- or third-degree atrioventricular block, sick sinus syndrome, or other serious cardiac rhythm disturbances, any history of Torsade de Pointes.
• . Treatment with any of the following drugs at the time of screening or the preceding 30 days, and/or planned use over the course of the trial: Treatment with Class IA or III antiarrhythmic drugs (e.g. quinidine), treatment with QT prolonging drugs (www.crediblemeds.org)- excluding SSRIs (e.g. Citalopram, Escitalopram, Paroxetine, Sertraline, Duloxetine, Trazodone, etc.). Should treatment with any of these agents be required, therapy with K0706 should be interrupted.
• . Females must not be lactating, pregnant or with possible pregnancy