Active — Not RecruitingPhase 1/2

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

United States, Canada, Czechia424 participantsStarted 2019-09-30

Plain-language summary

The purpose of this study is to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatments.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2 For participants in Cohorts A, B, C, D, E, F, H, I, J, and K the following inclusions will also apply: * Documented diagnosis of multiple myeloma (MM) and measurable disease * Documented disease progression during or after their last antimyeloma regimen * Achieved a response (minimal response \[MR\] or better) to at least 1 prior treatment regimen Exclusion Criteria: * Plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or clinically significant amyloidosis * Known central nervous system (CNS) involvement with myeloma * Received immunosuppressive medication within the last 14 days of initiating study treatment * Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment Other protocol-defined inclusion/exclusion criteria apply

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Recommended Dose

Timeframe: Up to approximately 3 years

Recommended regimen as measured by dose-limiting toxicities

Timeframe: Up to approximately 3 years

Number of participants with Adverse Events (AEs)

Timeframe: From first participant first visit until 28 days after the last subject discontinues study treatment, up to 5 years

Overall response rate (ORR)

Timeframe: Up to approximately 5 years

Trial details

NCT IDNCT03989414

SponsorCelgene

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2026-11-30

View on ClinicalTrials.gov More Multiple Myeloma trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Recommended Dose

Timeframe: Up to approximately 3 years

Recommended regimen as measured by dose-limiting toxicities

Timeframe: Up to approximately 3 years

Number of participants with Adverse Events (AEs)

Timeframe: From first participant first visit until 28 days after the last subject discontinues study treatment, up to 5 years

Overall response rate (ORR)

Timeframe: Up to approximately 5 years