Major trauma is associated with a release of alarmins (DAMPs - damage-associated molecular patterns) from the injured tissues. This process results in the activation of the immune system, which is one of the main mechanisms participating in the development of organ dysfunctions in patients with major trauma.
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Correlation between HMGB-1 and sCK/sMb levels
Timeframe: 24 hours
Correlation between sCK/sMb levels in relation to the degree and localisation of injury
Timeframe: 24 hours
Mutual comparison of predictive levels of sCK/sMb in relation to post-injury acute kidney injury defined by KDIGO criteria
Timeframe: 8 days
Mutual comparison of predictive levels of sCK/sMb in relation to serum and urine AKI biomarkers neutropil-gelatinase associated lipocalin (NGAL)
Timeframe: 8 days
Comparison of predictive levels of serum and urine NGAL in relation to post-injury acute kidney injury development defined by KDIGO criteria.
Timeframe: 8 days