UnknownNot Applicable

Delayed Cerebral Ischaemia and Coagulation Alterations After Aneurysmal Subarachnoid Haemorrhage

Finland62 participantsStarted 2019-06-10

Plain-language summary

Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years. There is still only a limited understanding of the mechanisms of secondary insults causing brain injury after SAH, also called delayed cerebral ischemia (DCI). In this study, the investigators are exploring the use of quantifiable biomarkers from blood and continuous EEG monitoring as tools for the diagnostics of DCI. Additionally, the investigators are looking into other clinical variables (eg. pain, heart function) as factors of DCI.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Admitted to the Tampere University Hospital ICU due to aneurysmal SAH * Acute subarachnoid haemorrhage (confirmed by computed tomography, CT, AND confirmed origin either with computed angiography (CTA) or digital subtraction angiography (DSA) * Definite or approximated time for the onset of symptoms and delay to ICU admission no more than 24 hours * Expected treatment time at least 120 hours in the Tampere University Hospital Exclusion Criteria: * Known pregnancy * Any long-term anticoagulant or antithrombotic medication, except for low-dose aspirin (under 150 mg/day) * Known active cancer or cirrhotic liver disease or end-stage renal disease requiring renal replacement therapy

What they're measuring

Incidence of delayed cerebral ischemia

Timeframe: 14 days

Trial details

NCT IDNCT03985176

SponsorTampere University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-03-31

View on ClinicalTrials.gov More Aneurysmal Subarachnoid Hemorrhage trials