RecruitingNot Applicable

Neural Control of Kidney Blood Flow During Exercise in African American Adults

United States32 participantsStarted 2024-09-30

Plain-language summary

The goal of this clinical trials is to learn if healthy young African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are: * Do healthy young AA adults have a larger decrease in kidney blood flow during exercise compared to W adults? * Do healthy young AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults? During two visits in the research lab, participants will: * Perform a fitness test * Perform cycling exercise while lying down * Undergo a cold hand test * Perform a mental math test Completing this clinical trial will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.

Who can participate

Age range

18 Years – 35 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Self-report as either African American or White racial identity * Born in United States * Both biological parents identify as same racial identity as participant * Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events) * Fluent in English Exclusion Criteria: * Hispanic or Latino * Females who are pregnant or lactating * Cardiovascular or renal disease * Hypertension (blood pressure of more than or equal to 130/80 mmHg) * Diabetes * Obesity (body mass index of more than or equal to 30 kg/m2) * Smoker/Tobacco user * Acute medical conditions * Taking prescribed cardiovascular, antihypertensive, or renal medications

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in renal vascular resistance during acute exercise

Timeframe: Pre-acute exercise and during steady-state exercise

Change in renal vascular resistance during cold pressor test

Timeframe: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test

Change in renal vascular resistance during mental stress test

Timeframe: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test

Trial details

NCT IDNCT03981640

SponsorUniversity of Massachusetts, Boston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08

Contact for this trial

Rachel C Drew, PhD

617-287-4061 rachel.drew@umb.edu

View on ClinicalTrials.gov More Healthy trials