CompletedPhase 1

A "Window Trial" on Curcumin for Invasive Breast Cancer Primary Tumors

United States22 participantsStarted 2020-01-29

Plain-language summary

The purpose of this study is to determine whether oral administration of curcumin causes biological changes in primary tumors of breast cancer patients.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Histologically confirmed invasive breast cancer (stages I, II, or III) with primary tumor(s) ≥ 1.0 cm on mammogram, ultrasound, MRI, or physical exam
✓. 18 years of age or older
✓. Subject must understand risks and benefits of the protocol and be able to give informed consent
✓. Women of childbearing potential (WOCBP) must agree to use an approved form of birth control and to have a negative pregnancy test result within 14 days of registration. WOCBP is defined as any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal. Menopause is defined clinically as 12 consecutive months of amenorrhea in a woman over 45 in the absence of other biological or physiological causes
✓. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
✓. Adequate hematologic and end organ function
✓. Ability and capacity to comply with the study and follow-up procedures
✓. Subjects must be scheduled for surgery at MUSC no less than 5 days from the planned start of day 1 and no more than 56 days from the planned start of day 1

Exclusion criteria

✕. Subjects undergoing neoadjuvant chemotherapy or neoadjuvant endocrine therapy
✕. Subjects with end-stage kidney disease and/or grade II liver dysfunction
✕. Subjects who are pregnant or are lactating.
✕. Subjects with bile duct obstruction, gallstones, predisposition to kidney stones(39), or gastrointestinal disorders such as stomach ulcers and hyperacidity disorders(40)
✕. Subjects taking anti-coagulants or platelet inhibitors
✕. Subjects taking drugs metabolized by CYP3A4, CYP1A2, and CYP2A6 enzymes
✕. Subjects taking drugs that interact with P-glycoprotein (P-gp)
✕. Subjects taking any of the medications listed under Other Herb-Drug interactions according to the Memorial Sloan Kettering Cancer Center in section 5.

What they're measuring

Change in tumor proliferation rate

Timeframe: Up to 56 days

Trial details

NCT IDNCT03980509

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-03-24

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