CompletedNot Applicable

Prediction Model Based on Computed Tomography Liver Volume for the Short-term Mortality in Hepatitis B Related Acute-on-Chronic

China486 participantsStarted 2019-03-01

Plain-language summary

HBV-related acute-on-chronic liver failure (HBV-ACLF) deteriorates rapidly with a high short-term mortality. Early identification and accurate prognostic prediction was critical to improve survival rate. This study was sought to determine the liver volumetry as predictor for short-term mortality in HBV-ACLF and develop a simpler prognostic model based on liver morphology. Liver volumetry were determined from CT at admission. Univariate and multivariate logistic regression were used to identify the optimum prognostic indicators and develop prognostic model. Additionally, receiver operating characteristic curves were analyzed to evaluate the predictive ability of the model.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓. age 18-70 years, male or female.
✓. Acute hepatic insult manifesting as jaundice and coagulopathy, complicated within 4 weeks by ascites, and/or encephalopathy in a patient with chronic HBV infection
✓. Abdominal CT examination was performed within 3 days after admission
✓. Biochemical examinations were available within 3 days before or after CT scan

Exclusion criteria

✕. Patients with evidence of non-B hepatitis virus: alcohol abuse leads to liver failure, autoimmune leads to liver failure, oxic or other causes that might lead to liver failure
✕. Past or current hepatocellular carcinoma
✕. Serious diseases in other organ systems
✕. Chronic liver failure
✕. There was no CT imaging data or the interval between CT scan and diagnosis of liver failure \>3 days

What they're measuring

Overall survival of ACLF subjects

Timeframe: 28 days

Trial details

NCT IDNCT03977857

SponsorFirst Affiliated Hospital Xi'an Jiaotong University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-12-31

View on ClinicalTrials.gov More Acute-on-Chronic Liver Failure trials