UnknownNot Applicable

Effects of a High or Low Salycilate Diet on Urinary LTE4 and Clinical Features in AERD

Mexico15 participantsStarted 2017-02-02

Plain-language summary

On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting. Group 1 will recieve a low-salycilate diet, and group 2 a high-salycilate diet. Two hours after each meal, urinary Leucotriene E4, FEV1, FVC, FEV1/FVC and total nasal resistance will be measured. On day 7, after clearance time, group 1 will recieve high-salycilate diet and group 2 low salycilate diet and the same measurements will be obtained.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Confirmed Aspirin exacerbated respiratory disease. * Controled asthma * No actual systemic corticosteroid treatment * No antileucotriene treatment. Exclusion Criteria: * Patients who do not complete both phases of the study * Patients unable to perform adecuate spyrometric testing * Patients who present severe asthmatic reactions with high salycilate foods

What they're measuring

Change from baseline in Urinary concentration of Leucotriene E4 (LTE4)

Timeframe: Baseline-4-8-12 hours in day one and Baseline-4-8-12 hours in day 7

Trial details

NCT IDNCT03973749

SponsorInstituto Nacional de Enfermedades Respiratorias

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2019-05-31

View on ClinicalTrials.gov More Aspirin-exacerbated Respiratory Disease trials