Standard- Versus Reduced-dose Tacrolimus Combined With Generic Mycophenolate Mofetil in De Novo Renal Transplantation

Inclusion Criteria: * Recipients (aged 20-65) of a single (first or second) renal allograft from living or deceased donor. Exclusion Criteria: * comprised of recipients with multiple organ transplants * double kidney transplant or organs donated after cardiac death * recipients previously organ transplanted except kidney * ABO-incompatible transplants * recipients with antibodies against the human leukocyte antigens of the donor organ * history of malignancy in the previous 5 years (except successfully treated localized non-melanoma skin cancer and thyroid cancer) * leukocyte counts of less than 2,500 per μL, or neutrophils less than 1,500 per μL, or platelets less than 50,000 per μL * evidence of active systemic infection requiring the use of antibiotics, human immunodeficiency virus infection, or chronic active hepatitis B or C