CompletedNot Applicable

Does Wrapping With Bone Marrow Injection Enhance Healing of Meniscal Sutures Into the Avascular Area

Switzerland96 participantsStarted 2017-07-18

Plain-language summary

This study will compare meniscal healing of non-vascularised area augmented or not by bone marrow injected under a protective collagen membrane (meniscal wrapping)

Who can participate

Age range

15 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Symptomatic or traumatic tears of medial or lateral meniscus; * Tearing affecting: only 2/3 central (= avascular zone) over more than 1 cm OR extending from the peripheral third (= vascularized area) within the avascular zone over more than 1 cm. In this case, preservation of the peripheral third over a width of at least 4 mm from the capsule; * Single or multiple tears. Exclusion Criteria: * Meniscal tears that can not be sutured, reduced / approximated * Tear creating a meniscal root avulsion * Partial meniscal tears * Meniscal tears already sutured * Cartilage damage in the compartment\> grade 2 (ICRS classification) * Mechanical axis (varus / valgus) ≥ 2 ° * Untreated ligament deficiency * Osteotomy and / or concomitant ligament reconstruction, with the exception of ACL reconstruction. * Compromised general health condition (score ASA score\> 2) * BMI ≥30 * Active smoking, drug use * Allergy to porcine collagen * Poor compliance

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in integrity and healing of meniscus repair

Timeframe: 12 and 24 months after treatment

Knee injury and Osteoarthritis Outcome Score (KOOS)

Timeframe: baseline and 3, 12 and 24 months after treatment

International Knee Documentation Committee Score (IKDC)

Timeframe: baseline and 3, 12 and 24 months after treatment

SF-12 Survey

Timeframe: baseline and 3, 12 and 24 months after treatment

Failure rate

Timeframe: up to 24 months

Trial details

NCT IDNCT03968029

SponsorCentre Hospitalier Universitaire Vaudois

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-19

View on ClinicalTrials.gov More Meniscus Lesion trials

Who can participate

Age range

15 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in integrity and healing of meniscus repair

Timeframe: 12 and 24 months after treatment

Knee injury and Osteoarthritis Outcome Score (KOOS)

Timeframe: baseline and 3, 12 and 24 months after treatment

International Knee Documentation Committee Score (IKDC)

Timeframe: baseline and 3, 12 and 24 months after treatment

SF-12 Survey

Timeframe: baseline and 3, 12 and 24 months after treatment

Failure rate

Timeframe: up to 24 months