TerminatedPhase 4

Avoiding Neuromuscular Blockers to Reduce Complications

Stopped: Study terminated due to lack of enrollment.

United States3 participantsStarted 2019-08-07

Plain-language summary

The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least 18 years of age * Undergoing non-cardiac surgery under general anesthesia with an endotracheal tube * those at higher risk of developing postoperative pulmonary complications (internally validated risk prediction score of \>=20) Exclusion Criteria: * Emergency surgery * Ambulatory (outpatient) surgery * Scheduled for elective postoperative ventilation * Planned return to operating room within 7 days of index procedure * Exposure to general anesthesia within 7 days prior to planned procedure * Requirement mechanical ventilation at baseline (not including stable use of CPAP/BiPAP) * Pregnant patients: as detected by patient self-reporting or diagnosed by preoperative pregnancy testing according to institutional policies at BIDMC and MGH * Allergy to either non-depolarizing muscle relaxants or sugammadex * Clinician refusal * Prisoner

What they're measuring

Number of participants who either had postoperative pulmonary complications or died in hospital within 28 days of index procedure.

Timeframe: 28 Days

Trial details

NCT IDNCT03962725

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-19

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