Behçet's syndrome (BS) is an idiopathic, chronic, multi-systemic inflammatory disorder characterized by ocular disease, skin lesions, vascular, neurological and gastrointestinal involvement. A recent study showed a peculiar dysbiosis of gut microbiota (GM) in BS patients, with specific changes in the profiles of short-chain fatty acids, especially butyrate. Over the last few years, a growing interest on the role of GM in metabolic disturbances has been manifested. Diet is one of the major factors driving the GM composition and functionality. In this context, the influence of diets generally recognized healthy on GM has been explored, but consistent data on autoimmune and inflammatory diseases are not available. The aim of this intervention study is to investigate whether a lacto-ovo-vegetarian diet enriched in substrates with potential for butyrate production or a Mediterranean diet supplemented with oral butyrate could be beneficial for GM and metabolic risk profile in BS.
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Disease severity of Behcet syndrome assessed by Behçet Disease Current Activity Form
Timeframe: 1 year
Behcet disease's improvement of symptoms assessed by the Global Assessment of Improvement Scale (GAI) modified form
Timeframe: 1 year
Behcet disease's severity of gastrointestinal symptoms assessed by the Symptom Severity Scale (SSS) modified form
Timeframe: 1 year