PanACEA Sutezolid Dose-finding and Combination Evaluation

Exclusion criteria

• . Circumstances that raise doubt about free, unconstrained consent to study participation (e.g. in a prisoner or mentally handicapped person)
• . Poor general condition where delay in treatment cannot be tolerated or death within three months is likely.
• . Poor social condition which would make it unlikely that the patient would be able to complete follow-up
• . The patient is pregnant or breast-feeding.
• . The patient is infected with HIV with a cluster of differentiation (CD) 4 count \<220 cells/mm3. If \>220 cells/mm3, patients will be included only if any of the following is applicable:
• . The patient has a known intolerance to any of the study drugs or concomitant disorders or conditions for which study drugs or standard TB treatment are contraindicated.
• . The patient has a history of, or current evidence of clinically relevant cardiovascular metabolic, gastrointestinal, neurological, psychiatric or endocrine diseases, malignancy, or any other condition that will influence treatment response, study adherence or survival in the judgement of the investigator, especially:
• . Conditions or history that predispose to epileptic seizures: personal or first-degree family history of epileptic seizures, stroke or transient ischemic attack, or history of severe traumatic head or brain injury, or meningitis/encephalitis, or others